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Home  >  Volume 28. No.1 (Nov. 2014)

28. Predicting the Number of Infected Cells of HIV Infection of CD4+ T-Cellsby A. Weli, B.C. Didia, E.O. Bennett, E.N. Ekaka-a1 - Volume28, No. 1, (November, 2014), pp 187 – 194
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Abstract 

The dynamics of infected cells of HIV infection of CD4

+ T-cells has been studied using the technique of a mathematical modelling. However, the weekly prediction of the number of infected cells of HIV infection of CD4+ T-cells that can be used as vital  data to manage and mitigate this endemic disease remains to be an open problem. In order to tackle this complex problem, we have used  a simulation analysis to successfully analyse this proposed problem. We havevaried the maximum proliferation rate of target cells denoted by ain the intervals of [0.68, 3.40] and [7.48, 

10.20] without random noise effects. The maximum proliferation rate of target cells interval of [7.48, 10.20] supports an increase in the number of infected cells of HIV infection indicating a dominant survival regime whereas the maximum proliferation rate of target cells interval of [0.68, 3.40] supports a decrease in the number of infected cells of HIV infection indicating a dominant regime in which a proportion of the predicted number of infected cells of HIV infection is destroyed. Another scenario 

corresponds to the interval of [0.68, 3.40] and theother scenarios when the maximum proliferation rates of target cells are 5.44 and 4.04 with a random noise intensity of 0.4. Our simulation study has indicated a decrease in the number of infected cells of HIV infection in contrast to the instances when themaximum proliferation rates of target cells are 54.4, 27.2, 13.6 and 8.16 that support the survival of the number of infected cells of HIV infection of CD4

+ T-cells. This present analysis has produced 

sufficient weekly data which can be utilized to build an effective database system for the purpose of the health planning of HIV infection. These novel contributions have not been seen elsewhere, they are presented here and discussed

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